Defective Mental Energy Storage and the Effect of Stimulants"A person with a defective system for storing mental energy might pace restlessly to keep their mind stimulated, or it may be that coffee or other nerve stimulants raise the energy level enough to allow calm integration." – Nutrition For Women |
Dark Roasted Coffee Provides the Daily Minimum Requirement of Vitamin B1"In a study on the thiamine content of dark roasted coffee, it was found that one or two cups cover the daily minimum requirement of vitamin B1." – Nutrition For Women |
Caffeine for the Relief of Hypertensive Headaches"Caffeine is actually prescribed in doses equivalent to two to four cups of coffee (200 to 400 mg) to relieve hypertensive headaches." – Nutrition For Women |
High Coffee Consumption and Improved Blood Flow to the Brain"Coffee improves blood flow to the brain; Benjamin Franklin and Goethe are said to have consumed 30 to 65 cups daily. This amount is close to the maximum safe daily caffeine dose of 6 grams." – Nutrition For Women |
Small Doses of Caffeine and Their Sedative Effect on the Brain"Very small doses of caffeine have a paradoxical sedative effect, but this is a familiar effect of anything that raises the brain's energy level." – Nutrition For Women |
The Effect of Caffeine on the Sympathetic Nervous System and cAMP Levels"Caffeine (which does not necessarily have the same physiological effect as coffee) stimulates the sympathetic nervous system and increases the cellular level of cyclic AMP." – Nutrition For Women |
The Metabolic Effects of Caffeine and Adrenaline on Sugar and Fat Utilization"Since both caffeine and adrenaline increase metabolism, fat is likely consumed faster. It is known that adrenaline raises blood sugar, apparently by inhibiting glucose utilization and increasing fat usage. Coffee usually raises blood sugar through its adrenaline-like effect." – Nutrition For Women |
Coffee and Adrenaline: Influence on Glycogen Breakdown During Fasting"During fasting, coffee and/or adrenaline can accelerate the breakdown of glycogen stores and thereby promote the occurrence of hypoglycemia." – Nutrition For Women |
The Role of Caffeine for the Immune System and Possible Cancer-Inhibiting Properties"Caffeine can increase immunity both through the nerves and by direct action. When injected into an animal's brain, it was found to slow cancer growth. Recently, it was accidentally discovered that a very small amount of caffeine mixed with the tars from cigarette smoke prevented this material from causing cancer." – Nutrition For Women |
The stimulating effect of caffeine on the thyroid"Caffeine stimulates the thyroid." – Nutrition For Women |
Amphetamines and their effects on appetite and hyperactivity"Amphetamines mimic the effect of the alarm part of the nervous system (sympathetic) and thereby increase blood sugar levels; this is probably the mechanism (or part of it) that suppresses appetite. Low blood sugar is associated with hyperactivity, and this is likely why the same drug is effective for hundreds of thousands of hyperactive children so they can sit still in school; coffee works just as well for hyperactivity and might also help dieters." – Nutrition For Women |
Substances that mitigate the harmful effects of carbon monoxide"Safe substances that reduce carbon monoxide or protect against its effects include methylene blue, caffeine, aspirin, progesterone, and red light." November 2017 – Ray Peat's Newsletter |
The inhibitory effect of stimulants on cell division and tumor growth"This effect of stimulants is probably also involved in their inhibition of cell division in cultured cancer cells (for example ephedrine and theophylline) as well as in caffeine's ability—when injected into the brain—to slow tumor growth elsewhere in the body." – Mind And Tissue Russian Research Perspectives on the Human Brain |
Fundamental therapies of sleep and nutrition for energy restoration"The oldest and most fundamental therapies, sleep and nutrition, have the same function, namely the restoration of energy reserves. Pavlov worked with the simplest stimulants and sedatives, such as caffeine and bromide, to restore normal nerve functions, and naturally always considered sensory stimulation essential for maintaining and restoring normal functions." – Mind And Tissue Russian Research Perspectives on the Human Brain |
Oxidative Processes and Factors of Enzyme Regulation"The oxidative processes that support the targeted, creative functioning of the organism optimize CO₂ by inhibiting carbonic anhydrase; this enzyme is inhibited by the thyroid hormone T3, progesterone, urea, caffeine, antipsychotic drugs, and aspirin. Substances that tend to cause a return to primitive anaerobic energy production activate the enzyme – for example serotonin, tryptophan, cysteine, histamine, estrogen, aldosterone, HIF, SSRIs, angiotensin, and parathyroid hormone." March 2020 – Ray Peat's Newsletter |
The influence of the gut and treatment approaches in Parkinson's"The gut can influence the brain, and we have discovered a variety of factors that damage the substantia nigra and cause Parkinson's syndrome, as well as some practices – drinking coffee or alcohol, smoking, taking aspirin – that significantly reduce the risk. These observations suggest there are effective ways to treat Parkinson's disease with diet, laxatives, and anti-inflammatory substances." March 2017 – Ray Peat's Newsletter |
Protective factors in Parkinson's generally act against estrogen"Things that are likely protective in Parkinson's disease generally also protect against estrogen and inflammatory-degenerative processes: progesterone, minocycline and other anti-inflammatory antibiotics, agmatine, aspirin, coffee, niacinamide, citrus flavonoids, vitamin D, ACE inhibitors, fiber-rich antiseptic foods." March 2017 – Ray Peat's Newsletter |
Protective substances against the consequences of impaired glucose oxidation"Other substances that protect against the effects of hypoglycemia or impaired glucose oxidation include progesterone, caffeine, certain anesthetics including xenon, niacinamide, agmatine, and carbon dioxide." January 2017 – Ray Peat's Newsletter |
Defense mechanisms against nitric oxide: the nutritional approach"Among the most important defense mechanisms against nitric oxide are progesterone, vitamin E, vitamin K, vitamin A, niacinamide, coffee, aspirin, as well as foods containing flavonoids, terpenoids, polyphenols, and sterols. Milk from grass-fed cows contains a variety of polyphenols. Citrus fruits, many tropical fruits (e.g., guavas, longans, and lychees), as well as cooked mushrooms, are good sources of apigenin, naringenin, and related substances." January 2016 – Ray Peat's Newsletter |
The calming effect of thyroid hormone on hypermetabolism“Although I tended toward hypermetabolism and was confused for years by the simultaneous appearance of signs of both hyper- and hypothyroidism, I eventually tried taking thyroid hormone. Immediately afterward, I was able to sleep easily and deeply, and my food requirements decreased. It was obvious that the thyroid had a calming effect on my entire metabolism. I slept more efficiently, woke refreshed, had plenty of energy during the day, and began to seek out household tasks purely for enjoyment. Before taking thyroid, the first thing I did every morning was drink two or three cups of coffee, but a few days after starting thyroid, I noticed I hardly thought about coffee and drank about 90% less without any withdrawal symptoms.” April 1994 – Ray Peat's Newsletter |
The Role of Ritalin in Improving Concentration through Brain Energy“Since the 1960s, a stimulant, Ritalin (methylphenidate), has often been prescribed to hyperactive children because it enables them to be calmly attentive. This effect has been called paradoxical, but from the perspective of scientific physiology, there was nothing paradoxical about it. The frontal lobes of the brain, the most highly developed part, give us the ability to plan and understand complex things that require sustained attention. Without this higher part of the brain, which has a very high energy demand, people and animals become hyperactive and unable to concentrate. Ritalin (or coffee) makes everyone, even the most gifted students, more attentive and focused. Caffeine and Ritalin temporarily increase the brain’s energy level.” April 1994 – Ray Peat's Newsletter |
Physiological Compensation for Diet-Related Drug-Like Substances“Physiology continuously compensates to maintain balanced functioning in the presence of a wide variety of drug-like substances in our diet. When the diet is suddenly changed by removing alcohol, caffeine, or other biologically active substances, our compensatory counter-cyclical adjustment becomes apparent.” June 1991 – Ray Peat's Newsletter |
Misconceptions about Dependence on Hormones and Supplements“Wishes reflect needs, although rarely in a fully rational way. The fact that something makes you feel better, and that you feel worse when you stop it, should not be taken as proof of its addictive effect, yet many people experience this with thyroid hormones, coffee, vitamins, and even ordinary foods.” June 1991 – Ray Peat's Newsletter |
Dynamics of Desire in Relation to Organismic Stability“The fact that a piece of chocolate can trigger a strong craving for more chocolate or that a cigarette renews addiction does not mean that the presence of chocolate or nicotine in the blood creates a craving. Rather, an organism in an unstable state perceives the availability of something that promises to partially restore the desired stability. It is obvious that smoking cigarettes is not a good way to achieve the needed stability, but this observation cannot be generalized to cravings for potato chips, coffee, or the many other things people often crave.” June 1991 – Ray Peat's Newsletter |
Possible therapeutic effects of caffeine in cystic breast disease“Other studies found no connection between caffeine and breast diseases, but I would not be surprised if it ultimately turns out that caffeine is therapeutically effective in certain forms of cystic breast disease, due to its effects on hormones and cell regulation.” May 1990 – Ray Peat's Newsletter |
The protective effect of caffeine against cancer in rats“Several studies have found that caffeine has a protective effect against cancer. For example, Würzner et al. found that tumor incidence in rats fed coffee decreased as the caffeine content increased.” May 1990 – Ray Peat's Newsletter |
The protective effects of caffeine against cancer and the stimulation of the immune system“Caffeine has several effects that protect against cancer. It strongly protects against cancers caused by chemical carcinogens (including those in smoke) and even those caused by ultraviolet radiation. It stimulates repair processes that correct mutations (in mammals, but not in bacteria), and it stimulates the immune system.” May 1990 – Ray Peat's Newsletter |
The beneficial effects of caffeine on the thyroid and inflammation“I think some of the beneficial effects of caffeine come from its stimulation of the thyroid and normal respiration. While it stimulates normal respiration, it has an anti-inflammatory effect that probably includes both the regulation of prostaglandins and an antioxidant effect. Chemically, it is very similar to our natural antioxidant uric acid and raises uric acid levels in the blood.” May 1990 – Ray Peat's Newsletter |
Ray Peat on Coffee
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